Liverpool boss Brendan Rodgers will restore a host of players after defeat to Swansea, with Steven Gerrard making his 600th appearance for the Reds.
Goalkeeper Pepe Reina and defender Glen Johnson may miss out again due to hamstring injuries.
Newcastle's top scorer Demba Ba is expected to win his battle with a minor calf problem and be passed fit to play.
The Magpies are again without midfielder Cheick Tiote, who serves the second game of a three-match ban.