West Ham defenders Winston Reid and Guy Demel face fitness tests on back and thigh injuries respectively.
Ricardo Vaz Te has had surgery on a dislocated shoulder and been ruled out for three months.
Southampton are without Gaston Ramirez for at least a month due to problems relating to a dead leg he suffered before the international break.
Danny Butterfield, Jack Cork, Tadanari Lee and Frazer Richardson are out, but Nathaniel Clyne could return.
MATCH PREVIEW

Side-by-side for most of last season in the Championship, it was Southampton who stayed the distance to clinch automatic promotion while West Ham had to take the harder, if more glamorous, route via the play-off final at Wembley.
And yet it's the Hammers that have adapted to life in the top-flight more impressively. They sit eighth in the table with three wins under their belt already, while the Saints are just one place and a point above the relegation zone.

I was at St Mary's to commentate on their only victory, a brilliant second-half display in which they brushed aside Aston Villa to win 4-1. That kind of attacking flair is what offers hope to manager Nigel Adkins.
Southampton look like they'll always score goals; his concern is that they seem even more prone to letting them in. Twenty goals conceded so far means they have the worst defensive record in the Premier League - 12 of those have come in their three away games.
Trips to Manchester City, Arsenal and Everton were always going to be challenging but on their day, in their own way, West Ham can be just as destructive. Ask Fulham. Andy Carroll terrified their defence at Upton Park on his debut and, now fully-fit again, the England striker will test Southampton's rickety backline.
It's a shame for the Saints that club-record signing Gaston Ramirez will be missing for the next month with a thigh injury, meaning much of the creative responsibility will fall on the shoulders of Adam Lallana.
If he's up to the task, and if Rickie Lambert can get a few sig