Sunderland have a doubt over Adam Johnson, who missed England's World Cup qualifiers with a thigh injury.
Full-back Danny Rose could make his Black Cats debut, while midfielder David Vaughan may figure after playing 45 minutes for Wales against Serbia.
Left-back Jose Enrique is Liverpool's main concern and will have his knee injury assessed ahead of the game.
But midfielder Joe Allen has recovered from the illness which disrupted his international involvement this week.
MATCH PREVIEW
After an incredibly emotional week for Liverpool as a city and a football club, Brendan Rodgers says he feels even greater pride at being their manager.
Rodgers is vying to record a first league victory at the fourth attempt. He goes head-to-head with fellow Irishman Martin O'Neill, who will be equally desperate for three points in Sunderland's first home game of the Premier League season, having last tasted victory back in March.
Only three games into the campaign, Rodgers has already had to deal with frustrations on and off the pitch. Whilst he has witnessed costly individual errors from players and the well-documented issues of the transfer window, one of his bigger tests is to manage expectation.
His challenge of re-shaping the club is a massive one. Liverpool have finished seventh, sixth and eighth in the last three seasons and were 17 points adrift of Champions League qualification last season - the furthest they have ever been away. It won't be a quick fix, but a first win on Saturday would be very timely with Manchester United visiting Anfield next weekend.
Like Liverpool last season, Sunderland have had to contend with the hindrance of a lack of goals, a theme that has existed ever since they sold Darren Bent. You could therefore fully understand the smile on Martin O'Neill's face when Steven Fletcher scored twice on his debut in the draw at Swansea.
The arrival of the striker from Wolves, and Adam Johnson from Manchester City, were badly needed and have raised hopes again o