Former Manus Island security guard Steve Kilburn said he could not see how the detention centre could function in a harmonious way.
"There is a big cultural difference that needs to be overcome between particularly the PNG locals and the transferees," he said.
"I think there are things that could be done to make life better and easier for everyone and my understanding is that some of those things have been done - there has been some improvements.
"But at the end of the day, and as I clearly stated, I can't see how this is ever going to work."