Kamran Khan began his career as a young vibrant investigative reporter for Karachi's Daily News newspapers in 1982, Mr. Kamran Khan almost immediately attracted the attention of top international newspapers and by 1985, he was already reporting from Pakistan for a top British newspaper, The Sunday Times, and a top U.S. newspaper, The Washington Post, simultaneously.However, He had been associated with Jang Group for the last 32 years which he mentioned in his last farewell message as well. On 27 July 2014, Kamran Khan Joined BOL Media Group as President and Editor-in-Chief.

In 1998, he became internationally and publicly known for his live coverage of nation's first publicly conducted nuclear tests: Chagai-I. During this time, he conducted several interviews with Pakistani scientists involved in this programme.