The Mother House of the Missionaries of Charity, located at 54A, A.J.C. Bose Road, Calcutta, is the headquarters of the international religious congregation of the Missionaries of Charity. It has been home to Mother Teresa and her sisters from February 1953 to the present day. It is here that Mother lived, prayed, worked, and guided her religious family of sisters spread across the world. It is here that her body was laid to rest.

On October 7, 1950, Mother Teresa and the small community formed by her former pupils was labeled as the Diocesan Congregation of the Calcutta Diocese, and thus received the permission from the Vatican to exist as a Church subject. Their mission was to care for (in Mother Teresa's words) "the hungry, the naked, the homeless, the crippled, the blind, the lepers, all those people who feel unwanted, unloved, uncared for throughout society, people that have become a burden to the society and are shunned by everyone." It began as a small community with 12 members in Calcutta, and today it has over 4,500 Sisters running orphanages, AIDS hospices, charity centres worldwide, and caring for refugees, the blind, disabled, aged, alcoholics, the poor and homeless and victims of floods, epidemics and famine in Asia, Africa, Latin America, North America, Europe and Australia.

In 1965, by granting a Decree of Praise, Pope Paul VI granted Mother Teresa's request to expand her congregation to other countries. The Congregation started to grow rapidly, with new homes opening all over the globe. The congregation's first house outside India was in Venezuela, and others followed in Rome and Tanzania, and eventually in many countries in Asia, Africa, and Europe, including Albania. In addition, the first home of the Missionaries of Charity in the United States was established in the South Bronx, New York. In the USA, the Missionaries of Charity are affiiated with the Council of Major Superiors of Women Religious, a body of female religious, representing 20% of