Recently, hedge fund manager and entrepreneur Martin Shkreli raised the price of a lifesaving pill more than 5,000 percent of what it used to cost. The backlash was huge and it's probably going to cost him, but The List’s Bradley Hasemeyer reports, there are other cases where people all on their own, took the road less traveled and turned up with empty pockets. From Apple to Harry Potter, we've got the 3 most famous business opportunities... now on the Lowdown!