Maude and Walter are all ready to take their second honeymoon to Rome. A tetanus shot Maude received as a prerequisite for travel gives her a rash, and when she encounters a busy doctor (Tom Bosley) who gives her medication without telling her correct dosage, her equilibrium becomes completely off balance, forcing both of them to cancel their trip. Out $800 for their deposit, they are enraged enough to sue the doctor for malpractice.