Mission Possible features the story of Catherine Tamayo, a mother who seeks to repair the rift in her relationship with her children. Tamayo's daughter Alexandra shares how she became resentful towards her mother after she left them at a young age. Despite the unfortunate events that forced her to leave her children, Tamayo is determined to regain their trust and to start a new life with them. The program then helps Tamayo to tighten her bond with her children through counseling, and gives them grocery items and livelihood packages.