Resident Evil: The Final Chapter is a 2016 action horror film written and directed by Paul W. S. Anderson. The direct sequel to Resident Evil: Retribution (2012), it is the sixth installment in the Resident Evil film series and the final installment in the original series, which is based on the video game series of the same name. The film stars Milla Jovovich, Iain Glen, Ali Larter, Shawn Roberts, Eoin Macken, Fraser James, Ruby Rose, Rola, and William Levy. In the film, Alice and her friends are betrayed by Albert Wesker, who gathers the entire forces of the Umbrella Corporation into one final strike against the apocalypse survivors.

A sixth film in the series was announced to be in development by Sony Pictures in 2012, and Anderson later expressed his desire for it to "come full circle", bringing back characters, themes and the environment of the Hive from the first film. It was filmed in 2D and post-converted to stereoscopic 3D, and principal photography commenced on September 18, 2015 in South Africa.

In a flashback, it is revealed that Dr. James Marcus, the founder of the Umbrella Corporation, had a daughter, Alicia, who was dying of progeria. Desperate to save her, Marcus confiscates an untested embryonic Umbrella project created by his colleague Dr. Charles Ashford—the T-virus—and uses it on Alicia and others with the disease. After one child treated with the virus dies and becomes a zombie, Marcus immediately orders the project be terminated, all data on it be destroyed and forbids Ashford from ever pursuing it again, devastating Ashford who needed the T-Virus to save his own daughter Angela. Marcus's partner, Dr. Alexander Isaacs, has Marcus murdered by Albert Wesker, adopts Alicia and takes over the Corporation. Alicia inherits her father's 50% ownership.

After being betrayed by Wesker in Washington D.C., Alice awakens. The Red Queen appears and tells her she has 48 hours to infiltrate the Hive, a facility beneath Raccoon City. The Umbrella Corporation has an airborne anti-virus that can kill every zombie, but is waiting for the last few remaining humans to be wiped out. As her body carries the virus, Alice does not expect to live after the mission.

While travelling, Alice is captured by Isaacs, learning the "Isaacs" she previously killed was a clone. She escapes his convoy and reaches Raccoon City, where she meets a group of survivors: Doc, Abigail, Christian, Cobalt, Razor, and Claire Redfield, who survived the attack on Arcadia. Isaacs' convoy approaches, trailed by a horde of zombies. Alice and the group defeat them and retrieves Isaacs' few human captives, though Cobalt dies in the process. Alice and crew enter the Hive, where Wesker is in control. He releases mutated guard dogs, killing Christian and a freed captive.