A group of young travelers embarks on what they believe will be the vacation of a lifetime, only to find themselves trapped in a high-altitude horror. As their plane soars through the skies, a top-secret experiment goes awry, unleashing a swarm of deadly spiders. With the pilots incapacitated, the passengers must band together to navigate the chaos and survive the relentless arachnid assault. The stakes rise as they confront the monstrous "mother" spider, a formidable creature measuring an astonishing 5 feet. Will they find a way to land safely, or will the spiders claim the skies?