Wertheim is the northernmost town in Baden-Württemberg and lies at the confluence of the Tauber and Main rivers, at the foothills of the Odenwald and Spessart mountains on the other side of the Main. Bordered by the Main to the north, the western part of the municipality, with the Wertheim plateau and the deeply carved valleys of the Main and Tauber rivers, belongs to the Sandstein-Spessart natural region.