The American College of Physicians (ACP) has issued a new guidance statement in the March 6 issue of Annals of Internal Medicine to encourage adults to get screened for colorectal cancer. Colorectal cancer is the second leading cause of cancer-related deaths for men and women in the United States. ACP recommends that physicians perform an individualized assessment of risk for colorectal cancer in all adults. Physicians should screen for colorectal cancer in average risk adults starting at the age of 50 and in high risk adults starting at the age of 40 or 10 years younger than the age at which the youngest affected relative was diagnosed with colorectal cancer. The guidance statement does not recommend continued screening for colorectal cancer in adults over the age of 75 or in adults with a life expectancy of less than 10 years because the potential harms of screening outweigh the potential benefits.