For 140 years, the Wertheim Historical Society and the city of Wertheim collected a nationally significant collection of items from the former county of Wertheim, ranging from buttons and mammoth teeth to large combine harvesters.

The museum is housed in five listed buildings in Wertheim's old town, covering an area of 2,200 m², and hosts two to three special exhibitions a year.
Right in the entrance area, the two rivers Main and Tauber set the theme of “water” and “shipping.”